Mukdahan is a significant gateway to Indochinese countries. The local people of Mukdahan actually have had a long relationship with the people in Savannakhet province of Lao PDR.

Mukdahan is home to 8 ethnic minorities;namely, Thai Isan, Phu Thai, Thai Kha, Kraso, Thai Kaloeng, Thai Yo, Thai Saek, and Thai Kula. and 7 amphoe:- Don Tan; Dong Luang; Khamcha-i; Mueang Mukdahan; Nikhom Kham Soi; Nong Sung; Wan Yai.

Mukdahan to other districts

North:  Connects to Sakon Nakhon and Nakhon Phanom provinces. South: Connects to Yasothon, Amnat Charoen, and Roi Et provinces.
East: Connects to Savannakhet province of Lao PDR. with the Mekong River as the border.
West: Connects to Kalasin and Roi Et provinces.